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Post by Nancy Park on Aug 25, 2012 10:37:10 GMT -8
I decided to start this thread because of a discussion on facebook recently. Have any of you seen any blood sugar issues after implantation? I had two strange things happen recently. Two older ferrets around 6 years old. One implanted to castrate, the other a rescue in great health. Neither ferret showed any signs of adrenal. Around 3 months post implanting there were blood sugar drops and both were put on prednisolone. Both after about 3 months then had blood sugar hikes and were weaned off the pred. Both are fine months later and the picture of health. The rescue early spay girl I can believe she possibly has early adrenal and it has been noted that adrenal can mask insulinoma and once the adrenal is in check from the implant the insulinoma comes forward. The implant is also supposed to normalize blood sugar so that may be what happened with her but the whole male I have a hard time believing he has adrenal. It was noted that blood sugar can be affected by kidney problems and intestinal issues. Any thoughts or experiences from anyone else?
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Post by jackie on Aug 25, 2012 21:13:02 GMT -8
Well some hormones can raise the blood glucose levels, so maybe by implanting him with des, it brought the hormones levels down faster than his body could adjust, causing the blood sugar drop. After a few months, his body adjusted to the des, hormones leveled out, so he didn't need the pred anymore.
Just a thought.
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Post by Nancy Park on Aug 26, 2012 12:32:41 GMT -8
Sounds reasonable. I'm not saying the Des did the blood sugar issue, just asking others if they had seen this too and to talk about possible reasons. When Des is implanted it actually causes a hormone spike and then levels off.
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Post by miamiferret2 on Apr 9, 2013 20:40:36 GMT -8
I asked Dr. Rene Gandolfi about this (he was involved in the adrenal studies and he knows alot about it. i think he and wagner have been using the implant the longest here in the U.S). he says that he has seen several ferrets show signs of insulinoma after receiving the implant. I think the *theory* is that some adrenal ferrets overproduce cortisol. cortisol is the body's natural "pred" raises BG and actually masks insulinoma. so when the adrenal disease is treated with deslorelin or lupron, the cortisol levels go back down to "normal" levels and then the insulinoma (which had been hidden the entire time) becomes exposed. i have seen this on Lupron as well.
I do not know whether this would occur in an intact ferret.
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Post by unclejoe on Apr 17, 2013 17:24:29 GMT -8
I asked Dr. Rene Gandolfi about this (he was involved in the adrenal studies and he knows alot about it. i think he and wagner have been using the implant the longest here in the U.S). he says that he has seen several ferrets show signs of insulinoma after receiving the implant. I think the *theory* is that some adrenal ferrets overproduce cortisol. cortisol is the body's natural "pred" raises BG and actually masks insulinoma. so when the adrenal disease is treated with deslorelin or lupron, the cortisol levels go back down to "normal" levels and then the insulinoma (which had been hidden the entire time) becomes exposed. i have seen this on Lupron as well. I do not know whether this would occur in an intact ferret. This makes sense to me, with the one course I've had on the endocrine system. In my time as a mod on a couple forums I have seen cases where this has occurred. I will direct a couple ferrents here for support. The most recent one only had the implant a week ago.
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